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Synapse serves as the host site for a variety of scientific collaborations individual research projects and DREAM challenges. The increase in the number of HER2neu genes called gene amplification can lead to an increased amount of HER2 protein on the surface of the cells and is thought to cause cell division shown below3 Gene amplification of HER2neu is also thought to alter the response of tumors to treatment.

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Our goal is to make biomedical research more transparent more reproducible and more accessible to a broader audience of scientists.

. The strategy presented can be applied to any number or kind of genes or tissues and should allow more accurate gene-expression profiling. These sequences ultimately lead to the production of all human proteins although several biological processes eg. In conclusion we described and validated a procedure to identify the most stable control genes in a given set of tissue samples and to determine the optimal number of genes required for reliable normalization of RT-PCR data.

Extra copies of the HER2neu gene are found in up to 20 of human breast cancers. Protein-coding sequences represent the most widely studied and best understood component of the human genome. Synapse is a platform for supporting scientific collaborations centered around shared biomedical data sets.

DNA rearrangements and alternative pre-mRNA splicing can lead to the production of many more unique proteins than the number of protein.

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Gene

Gene Definition Structure Expression Facts Britannica